STAT3 and Familial prostate cancer: For example, Scholz [8] and coworkers reported that activation of the Stat3 signaling pathway plays an important role in the progression of pancreatic cancer, and constitutive activation of Stat3 correlates with cell proliferation in stomach adenocarcinoma[9], prostate cancer[10], breast carcinoma[11], and non-small cell lung cancer[12] and also inhibits apoptosis[13,14].