In addition, it has recently been shown that down-regulation of BEX1 and BEX2 sensitize LNT-229 glioma cells to the chimeric tumor suppressor-1 (CST-1), a dominant-positive variant of p53, and up-regulation of BEX1 protects these cells to CST-1-induced cell death [22]. The gene discussed is CST1; the disease is central nervous system cancer.