BMI, WHR, total fat ratio, and trunk-fat ratio were each significantly associated with leptin (all P < 0.001) after adjustment for age, sex, height, ever smoked, diabetes, rheumatoid arthritis, cardiovascular disease, and asthma (data not shown), whereas only total fat and trunk-fat ratios were also associated with IL-6 (both P < 0.05). The gene discussed is LEP; the disease is diabetes mellitus.