L-4F in the presence or absence of pravastatin reduced IgG anti-dsDNA, IgG anti-oxPLs, and IgG anti-cardiolipin antibody production and symptoms of glomerulonephritis and osteopenia in our apoE-/-Fas-/- B6 murine lupus model of accelerated atherosclerosis. The gene discussed is APOE; the disease is atherosclerosis.