APOE and atherosclerosis: Independent of cholesterol-lowering effects, daily injections of simvastatin (intraperitoneally (i.p.)0.125 mg/kg/day) in young gld.apoE-/- B6 mice maintained on a high-fat diet for 12 weeks prevented the development of both atherosclerosis and lupus-like disease via a shift from Th1 to Th2 phenotype [7,19].