APOE and systemic lupus erythematosus: While traditional risk factors cannot fully predict the risk associated with the development of accelerated atherosclerosis in SLE, new mouse models, such as our apoE-/-Fas-/- B6 model, that exhibit both autoimmune manifestations and advanced atherogenesis, may aid in the understanding of pathways that contribute to the onset and progression of systemic autoimmune diseases with cardiovascular involvement.