We previously developed a risk-prediction algorithm for familial breast cancer and ovarian cancer - the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) - which can be used to compute the probabilities of carrying BRCA1 and BRCA2 mutations and the probabilities of developing breast cancer or ovarian cancer in the future [23]. Here, BRCA1 is linked to breast carcinoma.