Median Ang-2 concentrations (ng/ml (interquartile range (IQR)) were two-fold higher in patients with severe sepsis (12.4 (8.5 to 33.4)), than in those with sepsis without organ failure (6.1 (5.0 to 10.4); P < 0.0001), and 4.5-fold higher than in controls (2.7 (2.2 to 3.6), P < 0.0001). This evidence concerns the gene ANGPT2 and Sepsis.