On these bases, we identified three major tumor subgroups characterized by the predominant dysregulation of an ETS factor: i) tumors with high ERG expression (ERGhigh, n = 14), ii) tumors with high ESE-1 expression (ESE1high, n = 12) and iii) tumors with low ESE3 expression (ESE3low, n = 13). The gene discussed is EHF; the disease is neoplasm.