This candidate gene investigation of the chromosome 11 coeliac disease linkage region, which has been identified by several linkage studies [1-3], contains analysis of six genes; CD3E, CD3D, CD3G, IL10RA, THY1 and IL18. Haplotype tagging strategies were used to define haplotypes around the genes of interest, ensuring the maximum information content is gained. Here, IL18 is linked to celiac disease.