CRH and pituitary gland adenoma: In preclinical studies, pasireotide has shown significant inhibition of basal and stimulated ACTH release in human ACTH-secreting pituitary adenomas [66,67] and in AtT-20 murine corticotroph tumor cells [66,68], as well as significant inhibition of corticotropin-releasing hormone (CRH)-induced ACTH release in rats (Figure 1) [69,70].