Although H.pylori-associated gastritis coincides with a marked mucosal induction of IL17 and IL23 [140], and these cytokines are also elevated in gastric cancer bearing gp130Y757F mice (Putoczki T, Ernst M: A role for IL17 in a mouse model of gastric cancer, submitted), the latter tumours also develop in gp130Y757F;Rag-/- mice in the absence of adaptive immune cells [141]. The gene discussed is IL23A; the disease is gastric cancer.