Law suggested that SARS-CoV, during infection of dendritic cells, evades the immune response by down-regulating expression of the anti-viral chemokines IFN-α, β and γ and IL-12p40, while simultaneously up-regulating that of others: for example, TNF-α, IL-6, MIP-1α, and IP-10 [15]. The gene discussed is CCL3; the disease is infection.