According with the current guidelines published in February 2009 by the National Comprehensive Cancer Network (NCCN) [7], the recommended strategy for early detection of relapsed breast cancer involves history/physical examination, breast self-examination, mammography, and pelvic examination, while complete blood count, chemistry panel, bone scan, chest radiograph, liver ultrasound, CT scan, [18F]fluorodeoxyglucose PET scanning, magnetic resonance imaging, and tumor markers (CEA, CA15-3, TPA, etc) are not considered fundamental in the monitoring of breast cancer survivors. Here, CEACAM5 is linked to breast carcinoma.