However, several studies in the last decades have emphasized the role of the assessment of specific and appropriately used tumor markers as an easy, cheap, and significantly accurate tool for the early detection of distant metastases; recently, Nicolini et al. [8] showed that CA 15-3 as well as CEA, and TPA assessment contributes to an early diagnosis, which precedes by a few months, on average, clinical and/or instrumental signs of recurrent disease in 70% to 90% cases. The gene discussed is CEACAM5; the disease is neoplasm.