Our analysis in Caucasian individuals with hypertension AND without diabetes indicated that TCF7L2 rs7903146 was associated with focal arteriolar narrowing [ORCT vs. CC (95% CIs) = 1.40 (1.19, 1.64); ORTT vs. CC (95% CIs) = 1.96 (1.43, 2.68); P < 0.0001], which is consistent with our interaction analyses. The gene discussed is TCF7L2; the disease is Hypertension.