IGFBP3 was not associated with breast-cancer risk for premenopausal women (figure 2), but was associated with risk for postmenopausal women (OR in the highest fifth compared with the lowest of 1·23 (95% CI 1·04–1·45, test for trend p=0·012; test for heterogeneity by menopausal status at blood collection p=0·511). This evidence concerns the gene IGFBP3 and breast cancer.