By using DNA microarray technique to monitor changes in mRNA expression after tasquinimod exposure, in vitro to cultured human LNCaP cells or in vivo to LNCaP tumors grown in nude mice, we were able to identify TSP1 as one potential candidate, among many other differentially expressed genes, for mediating the tasquinimod-induced anti-tumor activity. Here, THBS1 is linked to neoplasm.