THBS1 and neoplasm: The tumor tissue levels of VEGF protein were not increased (Fig. 4B), whereas drug-induced changes in the tumor TSP1 mRNA expression at 10 mg/kg/day (p < 0.05; Fig. 4C (i)) and in protein levels at 1 and 10 mg/kg/day were significantly higher after 3 weeks exposure to tasquinimod (p < 0.001, ANOVA; Fig. 4D).