This is interesting since although different arguments reveal the pathological effect of IL-1β on cerebral malaria and severity of the disease in children [53], IL-1β together with other pro-inflammatory cytokines like IFN-γ and IL-6 is said to be protective against malaria by inducing parasite killing by monocytes, macrophages and neutrophils [54]. The gene discussed is IFNG; the disease is cerebral malaria.