This contribution of the CAPN10 variants to T2D pathogenesis was highlighted by the findings that select UCSNP-43/UCSNP-19/UCSNP -63 haplotypes (112 and 121) were associated with heightened risk of T2D in select ethnic groups, and as at-risk dipolotypes (haplotype combinations) were reported for many populations [10-13]. This evidence concerns the gene CAPN10 and type 2 diabetes mellitus.