In this case-control study, we examined the contribution of UCSNP-43, -19, and -63 CAPN10 variants on T2D risk in Tunisians of Arab origin, which were selected in view of previous reports linking them with T2D [4,7,14], insulin resistance [15], obesity [7,9,15], or with altered regulation of CAPN10 gene expression in Tunisian and other populations. The gene discussed is CAPN10; the disease is type 2 diabetes mellitus.