CD151 and hereditary clear cell renal cell carcinoma: CD151 functions as an important regulator of communication between tumor cells and endothelial cells, and might be as a potentially novel prognostic marker and target for therapy in breast cancer [16], biomarkers for assessment of malignancy in gingival squamous cell carcinoma (GSCC) [42], renal cell carcinoma [43] and metastasized colorectal carcinoma [18].