Comparison of the frequencies of 23 TRBV-BD1 sjTRECs in PBMCs between CML patients and normal controls at different amounts of DNA level showed that the frequencies of the most TRBV subfamily sjTRECs were significantly lower than those from healthy individuals, especially at the higher cellular concentration (2 × 105 PBMCs) (Figure 3). Here, DEFB1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.