There is increasing evidence that NRXN1 disruptions [Kim et al., 2008], point mutations [Feng et al., 2006; Yan et al., 2008], and deletions [Glessner et al., 2009; Marshall et al., 2008; Morrow et al., 2008; Szatmari et al., 2007] are associated with autism spectrum disorders. The gene discussed is NRXN1; the disease is autism spectrum disorder.