ANGPT2 and neoplasm: Mice treated with 0 mg/mL of Dox in the drinking water, hence those with xenografts expressing high levels of Ang2, had a significantly shorter survival time, and tumor proliferation was increased by 2.2-fold compared to the mice receiving either 1 or 10 mg/mL of Dox, which had comparable survival to controls (Figure 1(c) and Table 2).