Multivariate regression analysis using Cox's proportional hazards model revealed that VEGF (p = 0.032, HR = 4.779), CEA (p = 0.012, HR = 7.981), regional lymph nodes status (p < 0.001), and age (p = 0.005, HR 11.91) were independent prognostic factors for survival of colorectal cancer (Table 4). Here, CEACAM5 is linked to colorectal cancer.