Thus, the objective of the current study was to examine expression profiles of RECQL4, DOCK5, SPP1, RUNX2, RB1, CDKN1A, TP53, IBSP, LSAMP, MYC, TNFRSF1B, BMP2, HISTH2BE, FOS, CCNB1, and CDC5L genes in a cohort of osteosarcoma tumors and normal human osteoblasts. The gene discussed is RUNX2; the disease is osteosarcoma.