A. paniculata extract inhibits tumour specific angiogenesis by down-regulating various proangiogenic molecules such as vascular endothelial growth factor (VEGF), NO and proinflammatory cytokines and up-regulating anti-angiogenic molecules such as IL-2 and tissue inhibitors of metalloproteinase-1 (TIMP-1) which prevent tumour metastasis [56]. This evidence concerns the gene TIMP1 and neoplasm.