CDK1 and cervical squamous intraepithelial neoplasia: Cdk1 is known to affect chromosome transmission fidelity, and both aberrantly increased Cdk1 activity, e.g. in sic1Δ mutants, as well as reduced Cdk1 activity, e.g. in cdk1 point-mutants, leads to increased rates of chromosome loss [73,467-469], indicating that Cdk1 activity must be carefully balanced throughout the cell cycle in order to prevent CIN.