As shown in Fig. 1, α-synuclein, as well as the melanoma markers MART-1 and HMB-45, was strongly expressed in the malignant melanoma SK-MEL28 cell line, but was undetectable in the other cell lines, suggesting that α-synuclein is specifically expressed in malignant melanoma SK-MEL28 cells. The gene discussed is PMEL; the disease is melanoma.