Furthermore, although Rac1 ablation in the K14-Cre Rac1F/F mice does not cause any demonstrable effect in the architecture of the stratified epithelium of the oral mucosa [14], the absence of Rac1 in this epithelium which is devoid of HF and their stem cells, leads to a lack of ability to heal wounds, likely due to a decreased migratory, proliferative, or cell differentiating response of the Rac1-deficient epithelial cells. Here, RAC1 is linked to hydrops fetalis.