The T2D adipose causal subnetwork contains several co-expressed genes encoding key lipogenic enzymes, such as fatty acid synthase (Fasn), ATP citrate lyase (Acly), stearoyl-Coenzyme A desaturase 2 (Scd2), lanosterol synthase (Lss), farnesyl diphosphate synthetase (Fdps), and phospholipase A2, group V (Pla2g5). The gene discussed is LSS; the disease is type 2 diabetes mellitus.