INS and type 2 diabetes mellitus: The purple subnetwork was supported as the most strongly causal subnetwork for the T2D traits in the adipose coexpression network in the B6xBTBR cross (referred to here as the T2D adipose causal subnetwork), with 36% (Fisher Exact Test p = 5.26×10−68), 27% (Fisher Exact Test p = 1.40×10−50) and 29% (Fisher Exact Test p = 1.55×10−44) of the genes in this subnetwork supported as causal for plasma insulin levels, plasma glucose levels, and number of islets, respectively (Figure 3C, Table 2, Table S2).