ME1 and type 2 diabetes mellitus: In fact, the knockout gene expression signature for Me1 was significantly enriched for genes in the T2D adipose causal gene network, providing direct experimental evidence of the high degree of interconnectivity within this network, where perturbing one gene supported as causal for disease affects many other genes supported as causal in this network, as we have previously shown for other disease causal networks [12], [46].