Diffusion of shed sTNF-bound TNFR2 complex from the inner compartment to the outer compartment of granuloma can also explain the positive correlation of TNFR2 density in the core with the sTNF-bound fraction of TNFR1 in the outer compartment (output 3), while it is negatively correlated with the same response in the inner compartment (output 2) due to competition between receptors for binding to sTNF. Here, TNFRSF1A is linked to Granuloma.