For example, a whole-cell kinetic analysis of TNF/TNFR system with fitting to experimental data on human lung adenocarcinoma A549 cells has shown that the simplest model that reasonably explains the behavior of this system includes receptor synthesis and turn-over, TNF/TNFR association and dissociation as well as TNF/TNFR complex internalization, degradation and recycling of free receptors to the cell membrane [36]. This evidence concerns the gene TNFRSF1A and lung adenocarcinoma.