TNF and tuberculosis: To study the influence of TNF-associated molecular level processes on the availability of TNF, and thus TNF signaling within a TB granuloma, the distribution of sTNF in a granuloma was calculated by comparing modeling results in the presence of TNF intracellular trafficking with results of the model in the absence of TNF/TNFR internalization and shedding or TNF binding to TNF receptors.