Thus, the difference in binding properties of infliximab and etanercept must be considered when explaining the higher rate of TB reactivation induced from infliximab treatments in comparison with etanercept, although we anticipate that differential functional properties such as induction of apoptosis in TNF-producing cells by infliximab but not etanercept further influence the outcome of anti-TNF treatments [46], [86]. Here, TNF is linked to tuberculosis.