In contrast to previous reports suggesting that CARM1 activates the p53-mediated transcriptional response in H1299 lung cancer cells, CARM1 somehow inhibited the transcriptional activity of the p53 response elements (Fig. 5A) and subsequently the p21 promoter activity (Fig. 5B) (p values was 0.004 and 0.022, respectively). Here, TP53 is linked to lung carcinoma.