In oropharynx SCC, even with a small sample size, paired analysis showed Smad overexpression for Smad2 to 5, while in the entire HNSCC population, a significant difference was not achieved only for Smad8, confirming that differences between HNSCC subsites must be considered (Table 2). The gene discussed is SMAD9; the disease is head and neck squamous cell carcinoma.