Angiotensin-converting enzyme (ACE) inhibitors have long been known to be effective in the reduction of blood pressure and in the regression of left ventricular hypertrophy both in humans with essential hypertension [15] and in different animal models of arterial hypertension, such as SHR [16] and NO-deficient hypertensive rats [17]. The gene discussed is ACE; the disease is left ventricular hypertrophy.