Lee et al (2008) showed that a reduction in PHD2 leads to enhanced tumour growth and enhanced tumourigenesis. In reciprocal experiments, Matsumoto et al (2006, 2009) found that 2-oxogluturate, a substrate of PHD2, reduced both tumour growth and angiogenesis. Examining the effect of Phd2 deletion on endothelial cells directly, Takeda and Fong (2007) found that loss of Phd2 impaired proliferation. The gene discussed is EGLN1; the disease is neoplasm.