BCL2 and neoplasm: Constitutively activated STAT3 signalling in tumours has been shown to promote cell-cycle progression and prevent apoptosis by modulating cell cycle-associated and apoptosis-associated proteins such as cyclin D1 and Bcl-2; this is a possible mechanism of resistance to conventional chemotherapy and radiotherapy (Huang, 2007; Al Zaid Siddiquee and Turkson, 2008; Aggarwal et al, 2009).