LASP1 and cancer: Although LASP-1 sequence analysis revealed no nuclear localisation signal, the classical import pathway for the nucleus (Kutay and Guttinger, 2005), LASP-1 binds to the well-characterised shuttle proteins and transcription factors LPP and Zyxin that are upregulated in a wide variety of human cancers (Beckerle, 1997; Petit et al, 2003; Keicher et al, 2004; Li et al, 2004; Grunewald et al, 2009).