There are two facts regarding LASP-1 that seem to be linked: (a) the prominent nuclear localisation of LASP-1 in primary breast cancer (Figure 1) (Grunewald et al, 2007a) and (b) cell cycle arrest at G2/M accompanied by reduced cell proliferation after knockdown of LASP-1 in breast carcinoma cell lines (Grunewald et al, 2006). The gene discussed is LASP1; the disease is breast carcinoma.