TNFSF10 and melanoma: In our work, we first treated some melanoma cell lines with iz-TRAIL, a recombinant TRAIL fused with a synthetic isoleucine zipper that favours trimerisation, thereby enhancing its activity (Ganten et al, 2006), a phenomenon we had first reported for a different version of TRAIL together with an in vivo half-life of approximately 1 h (Walczak et al, 1997).