In T-ALL, increased expression of TLX1/HOX11 has been associated with favorable outcome [10,11,13,14], whilst aberrant expression of TAL1, LYL1 and TLX3 and deletions at 6q15-16.1 have been linked to poor prognosis [11,15,16]. This evidence concerns the gene TLX1 and acute lymphoblastic leukemia.