IGF2 and Beckwith-Wiedemann syndrome: Distal mouse Chr7 contains several key imprinted genes required for fetal development, two of which are also implicated in the etiology of BWS, the paternally expressed insulin-like growth factor-2 (Igf2) gene regulated by imprinting centre 1 (IC1, also known as H19 DMR) located upstream of the maternally expressed H19 gene and the maternally expressed cyclin-dependent kinase inhibitor 1C (Cdkn1c) which is regulated by imprinting centre 2 (IC2, also known as KvDMR1) located within intron 10 of the Kcnq1 gene [9,10].