Distal fibroblasts from COPD patients had a higher TGF-β1-response in the production of versican (p < 0.05), perlecan (p < 0.05), biglycan (p < 0.01), and decorin (p < 0.01) than central fibroblasts from COPD patients. The gene discussed is TGFB1; the disease is chronic obstructive pulmonary disease.