Interestingly, it has also been suggested that u-PA might catalyze the activation of the mesenchymal-derived cytokine hepatocyte growth factor/Scatter Factor (HGF/SF), thus facilitating invasiveness [22,23], an observation in line with the activation of HGF signaling in our tumours, as pointed out by the GenMapp analysis. The gene discussed is HGF; the disease is neoplasm.