LGR5 and malignant colon neoplasm: Notably, Lgr5, a marker of stem cells in colon epithelium [18] was also up-regulated in the arrays (FC = 10) as well as in RT-PCR experiments, demonstrating that cells presenting this stem marker are over-represented not only in Min mice intestinal tumours and human colon cancers [40,41], but also in DMH-induced colonic tumors.