IRF8 and neoplasm: IRF8-mediated inhibition of antigen presentation by dendritic cells in the tumor microenvironment has been described in human [57] but our results are not in concordance with a possible role of IRF8 in MHC class I repression since the repression in peptide presentation by class I molecules was linked with a down-regulation of IRF8 together with a down-regulation of the peptide processing cascade [57].