KDR and malignant colon neoplasm: In vivo preclinical experiments using EGFR and VEGFR inhibitors in colon cancer models reported several important findings: First, both receptors were present in tumor-associated mouse endothelial cells; and second, targeting both receptors with the tyrosine kinase inhibitor AEE788 reduced tumor growth and caused apoptosis in both tumor and endothelial cells [31].