Among them only a few number of genes are recognized as tumorigenic in several MM models: BCL2, BNIP3, FGFR3, MCL1, RAN and XBP1. BCL2 protein is the archetype of apoptosis regulatory molecules; it is an integral outer mitochondrial membrane protein that blocks the apoptotic death. This evidence concerns the gene FGFR3 and Miyoshi myopathy.