In the training cohort, Bcl-2 expression was identified in 90 (50%) of NSCLCs, including 51 (46%) adenocarcinomas (AC), 23 (62%) squamous cell carcinomas (SCC), 5 (45%) large cell carcinomas (LCC) and 6 (46%) adenosquamous carcinomas (AS). This evidence concerns the gene BCL2 and leukoencephalopathy with calcifications and cysts.