SKBR3, a known low Bcl-2 expressing breast cancer cell line Bcl-2[42] had an AQUA score of 18, whereas MCF7 and BT474 that are high Bcl-2 expressers [42] showed the highest AQUA scores for Bcl-2 expression (Figure 1B-C). This evidence concerns the gene BCL2 and breast carcinoma.