To assess intra-tumor heterogeneity for Bcl-2 expression, we compared AQUA scores from redundant tumor cores and observed significant correlation (Pearson's R = 0.85, p < 0.0001; Figure 1D and Pearson's R = 0.94, p < 0.0001 for the training and validation cohort respectively). This evidence concerns the gene BCL2 and neoplasm.