Little information is available about the transcriptional regulation of TCF4 apart from a report by Saegusa et al. [46] which showed in endometrial carcinoma cells that β-catenin can directly induce transcription from the TCF4 promoter in a positive feed-back loop, with the effect being enhanced by the p300 co-activator. The gene discussed is EP300; the disease is endometrial carcinoma.