In this study we focus on activity and anxiety in an automated homecage setup, cocaine-induced locomotor activity, and abdominal and subcutaneous white adipose tissue (WAT), parameters that are different between SERT-/- and SERT+/+ rats [18,22,23], cover a broad spectrum of phenotypes and are measurable in a high-throughput manner. Here, SLC6A4 is linked to Anxiety.