When testing the parental SERT+/+, SERT-/- and BN animals we found that SERT-/- rats compared to SERT+/+ rats showed significant differences for anxiety/locomotor activity (time time in shelter), exploratory pattern (immobility), cocaine-induced locomotor activity [22], and abdominal WAT deposition [23]. The gene discussed is SLC6A4; the disease is Anxiety.