Furthermore, IGF-I could effectively stimulate VEGF mRNA expression and protein secretion in human colorectal cancer cells expressing IGFIR molecules, which implied VEGF receptor VEGFR could also be up-regulated to promote the induction of angiogenesis, Therefore, VEGF and its receptor VEGFR may be a downstream molecule that is regulated by IGFIR signaling, and they may have synergistic effects in colorectal cancer growth and lymph node metastasis. The gene discussed is VEGFA; the disease is colorectal cancer.