IGF1R and metastatic malignant neoplasm in the lymph nodes: Thirty-one cases (65%) out of 48 samples positive for lymph node metastasis showed high expression of IGFIR in both colorectal cancer tissues and related metastatic lymph nodes, whereas only 14 cases (28%) for 50 samples of negative lymph node metastasis (P < 0.001; Table 2).