By immunohistochemical staining, we found that in human colorectal cancer samples that expressed high levels of both IGFIR and VEGF-C, 70% were positive for lymph node metastasis, and the co-expression of IGFIR and VEGF-C in the tumor correlated with an increased incidence of lymph node metastasis. The gene discussed is IGF1R; the disease is colorectal cancer.