Notably, when compared with both low or one of high expression of these markers, the concomitant high expressions of IGFIR and VEGF or IGFIR and VEGF-C was statistically significantly associated with lymph node metastasis in patients with colorectal cancer (Table 3; P < 0.001 for IGFIR/VEGF and P = 0.001 for IGFIR/VEGF-C). This evidence concerns the gene VEGFC and colorectal cancer.