In addition, our data showed that IGFIR high expression was positively correlated with VEGF-C high expression, and the expression of VEGF-C in mRNA and protein level also could be effectively induced by IGF-I in human colorectal cancer cells expressing IGFIR molecules, implying VEGF-C receptor VEGFR-3 could also be stimulated to promote lymphangiogenesis. Here, VEGFC is linked to colorectal cancer.