We further described the presence of anti-CL antibodies and AECA besides anti-U1RNP antibodies in MCTD; moreover, serum levels of anti-U1RNP antibodies, anti-CL IgG and AECA were higher in the MCTD/CVD+ group compared with MCTD/CVD- patients. Here, SNRNP70 is linked to mixed connective tissue disease.