In summary, correlation of mRNA and copy number identified numerous breast cancer tumor suppressor genes and oncogenes, such as STAT5A, SNIP, ZNF217, TOP2A, BCL2, PAK1, PER3, CCND1, NME1, PPAPDC1B, LSM1, IL17RB and FGFR1, to be significantly correlated in HER2+ tumors. The gene discussed is TOP2A; the disease is breast carcinoma.