Patients should be reminded to avoid behaviours that can contribute to hypoglycaemia, such as taking excess insulin, delaying or missing meals, etc. In addition, not only is mis-timing insulin/food intake around exercise a risk for hypoglycaemia (52) but patients are often unaware that hypoglycaemia can occur for up to 12 h after exercise; they should therefore be advised on appropriate action including additional monitoring before bed and appropriate increased food intake. This evidence concerns the gene INS and Hypoglycemia.